Key Features

Medications that contains Modafinil as an Active ingredient

• Modaheal 100 mg
• Modcare elite 250 mg
• Modacare 300 mg
• Modalit 200 mg
• Modasafe A 250 mg
• Modasmart 400 mg
• Modalert 100 mg
• Modvigil MD 200 mg
• Modavinil 200 mg
• Modalert 100 mg
• Modalert 200 mg 

How does Modafinil Work?

Modafil may enhances alertness, focus and wakefulness through modulation of several neurotransmitter system in brain.

• Modafinil may leads to inhibition of dopamine reuptake via DAT, tends to increase extracellular dopamine level especially in the nucleus accumbens.
• In tuberomammillary nucleus may activates histaminergic neurons that lead to arousal.
• Orexin or Hypocretin signaling may get enhanced.
• GABA release may get reduced and that tends to increase in glutamate release.
• Unlike Amphetamines it does not activates the sympathetic nervous system and there’s low risk of side effects, hypertension, tachycardia, or euphoria.

Usage

• It is used in the condition of Narcolepsy, Shift-work Disorder and Obstructive Sleep Apnea.
• It may enhance the focus and alertness during night shift.
• Attention Deficit Hyperactivity Disorder can be improved.
• Cognitive enhancement, may used by students and professionals.

Dosage

• The general starting dose in the condition of Narcolepsy, Obstructive Sleep Apnea Hypopnea Syndrome and Shift-work Disorder can be 100 mg.
• The dosage may increase from 100 mg to 200 mg as per the individual requirement and tolerant rate.
• Dosage may vary from individual to individual.

Side effects

• Headache
• Nausea
• Anxiety
• Insomnia
• Dizziness
• Dry Mouth
• Palpitations
• Diarrhea
• Psychosis
• Hallucinations

Interactions

• Metabolism of modafinil is primarily mediated through the enzyme CYP3A4, and it has the ability to act as a moderate inducer of CYP3A4
• Oral Contraceptives: Tends to decrease the effectiveness, other forms of contraception should be used.
• CYP3A4 Inhibitors like ketoconazole, itraconazole, and ritonavir may increase modafinil plasma levels and increase the risk of toxicity.
• CYP2C19 Substrates like diazepam, omeprazole, clopidogrel may interacts with modafinil adversely.

Precautions 

• The one with medical history of psychosis, depression, cardiovascular disease, hepatic impairment may avoid such medications.
• Pregnant and Breast feeding should also avoid such medications.
• Alcohol and Caffeine intake with modafinil may interact adversely.

Conclusion 

Modafinil is a vigilance promoting drug that tends to treat various sleeping conditions like Narcolepsy, Obstructive sleep Apnea, and Shift Work Disorder by improving alertness. It works by inhibiting sleep-inducing factors such as adenosine, thereby inducing wakefulness, it is while generally well-tolerated it is required to consult a medical professional or health care provider to avoid any unwanted interactions and for better results.